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Kwi 24

START!

Projekt pod tytułem: Nowatorskie metody inżynierii tkankowej wspomagające gojenie i regenerację ścięgien i więzadeł” wystartował.

Prace naukowe będą prowadzone przez 36 miesięcy.

Jednostki badawcze biorące udział w projekcie:

  • Politechnika Warszawska
  • Sport Medica S.A.
  • Centrum Onkologii – Instytut im. Marii Skłodowskiej-Curie
  • Uniwersytet Warszawski
  • Warszawski Uniwersytet Medyczny
  • Harvard Medical School
  • University of Pittsburgh

Angielskie podsumowanie projektu znajduje się poniżej.

Abstract:

Despite advances in treatment of tendon and ligament injuries, which are the most common musculoskeletal disorders that clinicians address daily, the question of optimal treatment is still unanswered. The main aim of the project is to develop a novel Scaffold-based Tissue engineering Approaches to healing and Regeneration of Tendons and ligaments (START). We hypothesize that in situ guided personalized tissue engineering, where smart, biodegradable patient/case–specific scaffold is used to provide biomimetic 3D micro- and nano-environments, and delivery required molecules and stem cells, would enhance the tendon/ligament regeneration. The bioactive scaffold will also recruit and stimulate endogenous stem/progenitor cells to assist tissue formation. Additionally, the scaffold, due to its special construction, will allow for continuous in situ modulation of regeneration by providing directly to injury site the stem cells, cytokines, and by applying mechanical stimulation to the tissue throughout whole time of therapy. The modulation will depend on results of in situ biomarkers analyzes. The START will also require the establishment of new non-invasive imaging and analytical techniques for in situ monitoring of regeneration processes. Implementing such multidisciplinary strategies for tissue engineering should greatly enhance the efficacy of treatment of tendon/ligament disorders.

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